When I fill my monthly generic prescription for oxycodone, I sometimes get pills made by different manufacturers. It seems like some work better than others, same dose - same drug! Does anyone else have this experience?
Oxycodone - Is there a difference in manufacturers of generic drugs?
Question posted by Anniebananie12 on 1 July 2013
Last updated on 22 November 2023 by Crystaltorrid
76 Answers
I haven't had that problem yet
Yes there is a big difference in all genetic medicine! They have different filters and most of them don’t work well at all ! So yes there is a big difference! I been dealing with this for the last 6 years!
I definitely had the same problem when I was on oxycodone I have fortunately been able to wean off this medication but when I was on it I always ask my pharmacy to obtain the Mallincrot brand it was definitely more effective than other brands I had received you may not be able to request a particular brand from one of the large pharmacies like CVS or Walgreens find a small mom and pop pharmacy that will help you you may have to try several before finding one that will work with you im the opioid situation we are in today don't be surprised if a pharmacy tells you that they don't stock opioids or they don't have them allot of the pharmacies today are reluctant to give that information out over the phone Good Luck and I hope this helps you because Mallincrot was definitely better than others I tried
That's so true about pharmacies being careful. Hell, doctors will normally try anything else first before giving out opioids, as they should. However, it also sucks because some people really need it to just live a normal life free from a lot of their pain and they can’t get it because of the crisis. I had to try 3-4 other drugs first and even was talked to about a spinal block before opioids were prescribed. Abundance of caution that I really appreciated from my doctor and Neuro. Sadly, I’ll be on this stuff til I’m pushing up daisies but I’m very careful to not overtake even at 40. This stuff really does help me live a better and more pain-free life but my god, it is addictive.
Mallinckrodt is as good as they come. Actavis were a little stronger but their not available here. Yes they can be addictive, but chances are slim, you well not addict. Everyone becomes dependent after a while, take as prescribed the best you can, don't worry about addiction. There's to much focus on that word, just go with the flow. You'll be fine!
I get the Mallinkrodt brand & I've found that it does in fact work way better than other kinds. I guess I'm lucky that's why my private pharmacy carries.
If you can get the 10-325 by Lupin laboratories, they are by far the best.
There are different manufacturers.
absolutely
YES, manufacturers of generic drugs are different. Although sometimes you will see a manufacturer requests a change to a drug under another name and when you do some digging, you find they are the same. Like Rhodes... it has several other names it uses to get changes approved to their drugs. You think people are overdosing on opioids. However, anyone who has had to take pain meds for long periods of time understand that not all opioids are alike. So imagine being in excruciating pain and your refill being a manufacturer that uses more fillers and those fillers make the drug less effective. A person that has no voice could take more and more just waiting on it to work. Not because they are trying to hurt themselves, but because they are trying to just have a pain free moment. Go with what you know… If you have taken something you know works, fight to keep it. You are the only one who knows how you feel.
I think they are different. The blue oxycodone 30s are way stronger feeling then the yellow ones
I get my meds through the 3-letter pharmacy (not sure if we can use the names) and in my past experience they typically only use Malinckrodt (sp?) and one or two other manufacturers. I honestly didn’t see any difference in the generics I was dispensed. Just wanted to add my experience as I’m guessing that most of those who respond will say there is a difference. I didn’t experience side effects or changes in effectiveness. They usually kicked in for the pain after about 30 minutes and lasted 4 hours. Never had one last a whole 6 hours. Also, never was dispensed the Percocet brand name so I can’t compare generics vs brand name.
Basically your asking, what’s the differences in oxycodone.? Because so many versions are many by many companies. Let’s say this, we know that
There’s many of the same dose
For example
10mg oxycodone/325mg Tylenol “Percocet” made by a company that designed this pill round with a cool imprinted C on one side and 320 on the other colored yellow. If we want to compare that 10mg/325mg Percocet, to say, a white capsule shaped this time with imprint IP204. They may look different but that example is two different pills, but in actuality they were exactly the same Exact active ingredients.
10mg oxycodone & 325mg Tylenol.
They should be zero difference in the amount between the two, and the only thing that is legal to be different by lay is the fillers and bindings to make the pill itself.
They should be the same but no one checks. The manufactures are self reporting and many have been busted lying. The other ingredients are extremely important as well but there's no way to get that info from anyone, I've tried for several years. There is no transparency! None. Any drugs could be full of nitrosodimethlamine and we'd never know. We've got some extreme issues that are potentially deadly and the government and it's agencies simply couldn't care less. Don't get sick in this country.
While the basic drugs are the same, the way they’re manufactured with fillers and binders may greatly affect their metabolism in the human body.
However all extra ingredients must be published in package instructions.
Our US FDA does require that. HOWEVER a specific drug’s efficacy, metabolism, shelf life is NOT revealed and possibly never researched. No prescribing health care provider or pharmacist knows either. I mentored with a nationally renowned asthma/allergy doctor who on his own studied the efficacy of different theophyllines (aminophyllines) but it was a small study of only 10,000 patients. That’s SMALL.
While the basic drugs are the same, the way they’re manufactured with fillers and binders may greatly affect their metabolism in the human body.
However all extra ingredients must be published in package instructions.
Our US FDA does require that. HOWEVER a specific drug’s efficacy, metabolism, shelf life is NOT revealed and possibly never researched. No prescribing health care provider or pharmacist knows either. I mentored with a nationally renowned asthma/allergy doctor who on his own studied the efficacy of different theophyllines (aminophyllines) but it was a small study of only 10,000 patients. That’s SMALL.
The medications are not the same. The oxycodone and hydrocodone vary in strength from manufacture to manufacture. The government, the doctor's and pharmacist all know this is taken place. The pharmacy will generally accept the cheapest price they can get. Unless consumers complain about a certain product, nothing will change. This started many years ago when all the lawsuits were filed and are still being filed. Until very recently I was able to get the yellow V 36 01 made by Endo thru merger and buyout. Good quality will be hard to find. Some pills do work better than others, not by much.
Hey Annie
I've had that happen with oxy and soma a couple of times over the years. If you have been going to the same pharmacist for a long time, you should just bring it to his/her attention. And, sometimes they can go to a different manufacturer. Because of people who truly have conditions that require these trusted medicines, our wonderful dictator government has been limiting the manufacturers that pharmacies can order from. It was never like this years ago. But, it's just another tactic to try and continue to punish citizens and, the pharmacies that actually still try to help their patients. Which is what they were trained to do for years. But, if you have a good pharmacist, they usually will try and change to another company. Let me know
Yes I feel when pharmacy switches. I don't get as much relief with most... but the cost for Brand name ... I sure can't afford...
NOT ALL PERCOCET IS CREATED EQUAL! WHY GENERICS ARE INFERIOR
All Percocet is made with the same ACTIVE ingredients; BUT NOT ALL PERCOCET is made using the same FORMULA.
FORMULA is the KEY. Here is why:
The FORMULA consists of all the INGREDIENTS used to make each pill, AND NOT ALL MANUFACTURERS USE THE SAME FORMULA.
To maximize profits, pharmacies buy the cheapest drugs they can find. In order to make the cheapest drugs, manufacturers simply leave out certain ingredients.
Anytime a manufacturer leaves out ingredients, THE DRUG WILL NOT WORK as it was originally designed to work.
By law, generic drugs sold to the public only have to contain the ACTIVE ingredient. They do not have to contain the original formula that the original drug maker spent years and billions of dollars on to ensure that the drug worked properly.
The missing ingredients are what often act as a DELIVERY SYSTEM. Delivery systems are developed to insure that the drug gets absorbed into the blood stream in a very specific way. It may ensure the drug gets absorbed quickly, or it may prevent the drug from being digested too soon, as some drugs only work when they are absorbed further down in the digestive tract.
WHAT YOU CAN DO:
Tell your provider that you want the BRAND NAME drug, not the generic. Often, the brand name is the same price, as it is for Percocet. Ask your provider to write for ENDOCET or PERCOCET, and to put NS, or “No Substitutions” on the Rx. Just be prepared for when the pharmacist tells you, “We don’t have those,” or “We will have to order those,” or “We can’t get those.” Find a pharmacy that can or does.
Patients should be treated honestly, not just as a source for turning poor quality drugs into cash.
The prices of brand name has gotten to high , never in stock here in Louisiana, also the pharmacy can only Oder x amount and that’s it for the month, I call 14 different drug store in one day ! Luckily to get them any at all
Absolutely there is a difference. Some are oblong white some are round yellow. My pharmacy switched manufacturer after 12 years and now all of a sudden this month I have developed severe feet edema and that's NEVER happened in all the years I've been on it until it came from different manufacturer.
Related topics
oxycodone, chronic pain, generic, prescription
Further information
- Oxycodone uses and safety info
- Oxycodone prescribing info & package insert (for Health Professionals)
- Side effects of Oxycodone (detailed)
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